Sodium Hydroxide → 2-{[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyric acid

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Ethyl 2-{[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyrate	HCID 14012534	—
Solvent	Methanol	HCID 887	—
Product	2-{[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyric acid	HCID 14012535	—

Reaction Steps

A solution of 3.6 g of ethyl-2-{[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyrate, 30 ml of 15% sodium hydroxide solution and 30 ml of methanol, is stirred under reflux for 3 hr. The methanol is evaporated and the solution is poured into dilute hydrochloric acid/ice affording a flocculant precipitate. The precipitate is collected, dried in vacuo and recrystallized from toluene to afford 2-{[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyric acid, mp 144° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04673746
Source dataset	uspto-grants-1987_06
ORD ID	ord-d233dc85c2e64a4399c2235fccf62a96
Source note	uspto-grants-1987_06