反应详情

In an argon atmosphere, 3.00 g (13.4 mmol) of 3,5-dimethoxy-4-hydroxycinnamic acid was suspended in a sulfuric acid - ethanol (1 : 115, 50 ml) solution. The suspension was refluxed for 5.5 hours. Water was added to the reaction solution, and the mixture was extracted with methylene chloride. The organic layer was washed with an aqueous solution of sodium hydrogen carbonate and concentrated under reduced pressure to give 3.34 g (13.24 mmol) of ethyl 3,5-dimethoxy-4-hydroxycinnamate.

1. temperatureThe suspension was refluxed for 5.5 hours
2. extractionthe mixture was extracted with methylene chloride
3. washThe organic layer was washed with an aqueous solution of sodium hydrogen carbonate
4. concentrationconcentrated under reduced pressure