反应详情

To a solution of 424 mg (1.43 mmol) of N-(2-benzhydroxyethyl) piperazine in dry dimethylformamide (2 ml) was added 475 mg (1.15 mmol) of N-[3-[3,5-dimethoxy-4-(β-methoxyethoxymethoxy) phenyl]-2-propenoyl]thiazolidine-2-thione, and the mixture was reacted at room temperature for 2 hours under argon atmosphere. The reaction mixture was concentrated by evaporation under reduced pressure and the residue was subjected to silica gel column chromatography, eluted with chloroform-methanol (100 : 1), to give 588 mg (0.995 mmol) of N-[3[3,5-dimethoxy-4-(β-methoxyethoxymethoxy)phenyl]-2-propenoyl]-N'-(2-benzhydroxyethyl) piperazine.

1. customthe mixture was reacted at room temperature for 2 hours under argon atmosphere
2. concentrationThe reaction mixture was concentrated by evaporation under reduced pressure
3. washeluted with chloroform-methanol (100 : 1)