反应详情

To a solution of 794 mg (2.68 mmol) of N-(2-benzhydroxyethyl)piperazine in dry dimethylformamide (4 ml) was added, under argon atmosphere, a solution of 1.15 g (2.61 mmol) of N[5-[3,5-dimethoxy-4-(β-methoxyethoxymethoxy)phenyl]-2,4-pentadienoyl)thiazolidine in dry dimethylformamide (4 ml), and the mixture was allowed to react at room temperature for 17 hours. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure and the residue was subjected to silica gel column chromatography, eluted with chloroform-methanol (100:1), to give 413 mg (0.670 mmol) of N-[5-[3,5-dimethoxy-4-(β-methoxyethoxymethoxy)phenyl]-2,4-pentadienoyl]-N'-(2-benzhydroxyethyl)piperazine.

1. customto react at room temperature for 17 hours
2. concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
3. washeluted with chloroform-methanol (100:1)