Sodium → HCID 13577522, compound

HRID 653010Notes

Reaction equation

HRID 653010 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]([S:11][CH2:12][CH2:13]Cl)=[N:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[Na]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[S:11][CH2:12][CH2:13][O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 86740658HCID 86740658, compound

Product 1

HCID 13577522HCID 13577522, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Cyclisation of 2-chloroethyl 3-fluoro-N-hydroxybenzenecarboximidothioate was accomplished as described in Example 2 using sodium (4.6 g) in ethanol (300 ml) to give 3-(3-fluorophenyl)-5,6-dihydro-1,4,2-oxathiazine, mp 47°-9° C. (Found: C, 54.66; H, 4.13; N, 7.07. C9H8FNOS requires C, 54.81; H, 4.09; N, 7.10).

Sources & evidence

ORD record
ord-7e85ab406a6d4705ba1106e4e222e698
Source dataset
uspto-grants-1987_06
Patent number
US04675044

Reaction notes

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