Phenylhydrazine → N-(2-Methoxyethyl)-2-phenylhydrazinecarbothioamide

HRID 653052Notes

Reaction equation

HRID 653052 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]=[C:6]=[S:7].[C:8]1([NH:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1C=CC=CC=1>[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6](=[S:7])[NH:15][NH:14][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 7516PhenylhydrazineHCID 1234752-Methoxyethyl isothiocyanate

Product 1

HCID 5296396N-(2-Methoxyethyl)-2-phenylhydrazinecarbothioamide

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In benzene was dissolved 11.7 g of 2-methoxyethyl isothiocyanate with stirring and after adding thereto 11.9 g of phenylhydrazine at room temperature, the mixture was heat-refluxed. After performing the reaction for 6 hours, the reaction mixture was cooled and crystals thus formed were collected by filtration. The yield for the product was 66.7%. The product, 4-(2-methoxyethyl)-1-phenylthiosemicarbazide thus obtained could be used for the subsequent reaction without being purified.

Workup

  1. additionafter adding
  2. customthe reaction for 6 hours
  3. temperaturethe reaction mixture was cooled
  4. customcrystals thus formed
  5. filtrationwere collected by filtration
  6. customThe yield for the product

Sources & evidence

ORD record
ord-16a5dfaf2fba459fb2e0253850e6fd3b
Source dataset
uspto-grants-1987_06
Patent number
US04675276

Reaction notes

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