反应详情

1-{2-Hydroxy-3-propyl-4-[3-(4-nitrophenoxy)propoxy]phenyl}ethanone (19.6 g) was dissolved in a mixture of ethanol (300 ml) and dimethylformamide (100 ml), to which was added under nitrogen, a slurry of palladium on charcoal catalyst (1.0 g, 5%) in ethanol (50 ml). The suspension was then hydrogenated on a Parr at 60 psi and room temperature for 90 minutes. The suspension was filtered over Celite (registered Trade Mark), washed with ethanol and the filtrate evaporated under reduced pressure to a brown oil, which was triturated with water and filtered to give a brown solid. The solid was recrystallised from ethanol with charcoal to give a white solid, m.p. 75°-77° C.

1. additionwas added under nitrogen
2. filtrationThe suspension was filtered over Celite (registered Trade Mark)
3. washwashed with ethanol
4. customthe filtrate evaporated under reduced pressure to a brown oil, which
5. customwas triturated with water
6. filtrationfiltered
7. customto give a brown solid
8. customThe solid was recrystallised from ethanol with charcoal
9. customto give a white solid, m.p. 75°-77° C.