反应详情

1-[2-Hydroxy-3-propyl-4-(4-bromomethylphenylmethoxy)phenyl]ethanone (7.2 g; 0.02 m) and potassium cyanide (2.5 g; 0.04 m) where dissolved in dry dimethylsulphoxide (60 ml) and stirred at room temperature for 2 hours. The solution was poured onto water with stirring and filtered to give a cream solid, which was dried at 60° C. under reduced pressure; Recrystallised from ethanol to give a pale cream crystalline solid m.p. 75°-76° C.

1. additionThe solution was poured onto water
2. stirringwith stirring
3. filtrationfiltered
4. customto give a cream solid, which
5. customwas dried at 60° C. under reduced pressure
6. customRecrystallised from ethanol