Acetic Anhydride → HCID 13531620, compound

HRID 653102Notes

Reaction equation

HRID 653102 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].Cl.[NH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]2[O:18][C:17]([N+:19]([O-:21])=[O:20])=[C:16]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:15]=2[CH:28]=1>C(O)(C)C>[C:1]([NH:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]2[O:18][C:17]([N+:19]([O-:21])=[O:20])=[C:16]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:15]=2[CH:28]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13531642HCID 13531642, compound

Product 1

HCID 13531620HCID 13531620, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 5 ml. of acetic anhydride and 0.3 g. of 5-aminomethyl-2-nitro-3-phenylbenzofuran hydrochloride (from Example 17) is heated on a steam bath for about 30 minutes. The mixture is then partially evaporated to provide a residue which is treated with aqueous isopropanol to form yellow crystals of 5-acetamidomethyl-2-nitro-3-phenylbenzofuran, m.p. 201°-203° C., having the structure

Workup

  1. additionA mixture of 5 ml
  2. customThe mixture is then partially evaporated
  3. customto provide a residue which

Sources & evidence

ORD record
ord-33016d0319f549e289cf3362ad8838fa
Source dataset
uspto-grants-1987_06
Patent number
US04675320

Reaction notes

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