反应详情

A mixture of 3-dimethylaminomethylene-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (2.838 g), hydrazine hydrate (0.66 g), and acetic acid (0.792 g) in methanol (30 ml) was stirred at room temperature for 3 hours. To the mixture was added acetic acid (1 ml) and evaporated in vacuo. The residue was dissolved in ethyl acetate, washed successively with aqueous sodium bicarbonate, water, and brine, dried over magnesium sulfate, and evaporated in vacuo. The residue was recrystallized from ethyl acetate to give 4,5-dihydro-5-propionyl-1H-pyrazolo[4,3-c]quinoline (1.77 g).

1. customevaporated in vacuo
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed successively with aqueous sodium bicarbonate, water, and brine
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo
6. customThe residue was recrystallized from ethyl acetate