HCID 178418600, compound → HCID 178487258, compound

HRID 653153Notes

Reaction equation

HRID 653153 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:7]([C:18]([NH:20][C:21]1[NH:25][N:24]=[N:23][N:22]=1)=[O:19])=[C:6]2[O:26][CH:27]([CH3:29])[CH3:28].[NH2:30][C@H:31]([C:39]([OH:41])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:38])[NH2:37]>CO.O>[NH2:30][C@H:31]([C:39]([OH:41])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:38].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:7]([C:18]([NH:20][C:21]1[NH:25][N:24]=[N:23][N:22]=1)=[O:19])=[C:6]2[O:26][CH:27]([CH3:29])[CH3:28]

Participants

5

Reactant 2

HCID 178418600HCID 178418600, compoundHCID 178487257HCID 178487257, compound

Product 1

HCID 178487258HCID 178487258, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A suspension of 2.76 g (0.007 mole) of 5-methoxy-3-(1-methylethoxy)-1-phenyl-N-1H-tetrazol-5-yl-1H-indole-2-carboxamide in 40 ml of methanol was warmed on a steam bath and treated with a solution of 1.22 g (0.007 mole) of L-arginine dissolved in a minimum of hot water. The mixture was digested until nearly one phase and filtered hot. Cooling to room temperature resulted in precipitation of the arginine salt product. The solid was filtered and washed several times with cold acetone to yield 2.77 g (70% yield) of analytically pure arginine salt, containing 0.50 mole of water of hydration, mp 218° C.-dec.

Workup

  1. temperaturewas warmed on a steam bath
  2. filtrationfiltered hot

Sources & evidence

ORD record
ord-11974ee61f444fd78e52e7a76281de9b
Source dataset
uspto-grants-1987_06
Patent number
US04675332

Reaction notes

Loading…