HCID 178418600, compound → HCID 178487258, compound

Participants

Reaction Steps

A suspension of 2.76 g (0.007 mole) of 5-methoxy-3-(1-methylethoxy)-1-phenyl-N-1H-tetrazol-5-yl-1H-indole-2-carboxamide in 40 ml of methanol was warmed on a steam bath and treated with a solution of 1.22 g (0.007 mole) of L-arginine dissolved in a minimum of hot water. The mixture was digested until nearly one phase and filtered hot. Cooling to room temperature resulted in precipitation of the arginine salt product. The solid was filtered and washed several times with cold acetone to yield 2.77 g (70% yield) of analytically pure arginine salt, containing 0.50 mole of water of hydration, mp 218° C.-dec.

Provenance & Evidence