Ethanol → HCID 178467032, compound

HRID 653154Notes

Reaction equation

HRID 653154 reaction equation
[CH2:1]([O:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:5]=1[C:21]([NH:23][C:24]1[NH:28][N:27]=[N:26][N:25]=1)=[O:22])[CH3:2].[NH2:29][C@H:30]([C:38]([OH:40])=[O:39])[CH2:31][CH2:32][CH2:33][NH:34][C:35](=[NH:37])[NH2:36].C(O)C>CO>[NH2:29][C@H:30]([C:38]([OH:40])=[O:39])[CH2:31][CH2:32][CH2:33][NH:34][C:35](=[NH:36])[NH2:37].[CH2:1]([O:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:5]=1[C:21]([NH:23][C:24]1[NH:28][N:27]=[N:26][N:25]=1)=[O:22])[CH3:2]

Participants

5

Reactant 3

HCID 702EthanolHCID 178418600HCID 178418600, compoundHCID 178467031HCID 178467031, compound

Product 1

HCID 178467032HCID 178467032, compoundYield 63.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared by the procedure described in Example 26 from 2.8 g (0.0074 mole) of 3-ethoxy-5-methoxy-1-phenyl-N-1H-tetrazol-5-yl-1H-indole-2-carboxamide and 1.3 g (0.0075 mole) of L-arginine, except that the solvent was ethanol rather than methanol. There was obtained 2.6 g (63% yield) of the arginine salt product, analytically pure containing 1.0 equivalent of water of hydration, mp 165° C.-dec.

Workup

  1. customPrepared by the procedure

Sources & evidence

ORD record
ord-dc85671393274cc4bd01eb87fede3ef0
Source dataset
uspto-grants-1987_06
Patent number
US04675332

Reaction notes

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