Chloral Hydrate → HCID 57046400, compound

HRID 653194Notes

Reaction equation

HRID 653194 reaction equation
[Cl:1][C:2]([Cl:7])([Cl:6])[CH:3](O)O.[C:8]1([CH3:19])[CH:13]=[CH:12][C:11]([S:14]([NH:17][NH2:18])(=[O:16])=[O:15])=[CH:10][CH:9]=1>CO>[C:8]1([CH3:19])[CH:9]=[CH:10][C:11]([S:14]([NH:17][N:18]=[CH:3][C:2]([Cl:7])([Cl:6])[Cl:1])(=[O:15])=[O:16])=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 2707Chloral HydrateHCID 15303P-Toluenesulfonylhydrazide

Product 1

HCID 57046400HCID 57046400, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol were dissolved 0.91 g (5.5 mmole) of chloral hydrate and 0.93 g (5 mmole) of p-toluenesulfonylhydrazine, and the mixture was stirred at room temperature for 60 minutes to form trichloroacetaldehyde-p-toluenesulfonylhydrazone. The reaction mixture was added to the solution of 2.35 g (16.5 mmole) of potassium disulfide dissolved in 20 ml of water for 20 minutes while maintaining the pH within 10 to 11 under room temperature, and the reaction was further continued while maintaining the pH of the reaction system within 10 to 11 by using an aqueous potassium hydroxide solution. The analysis after completion of the reaction was carried out in the same manner as in Example 1. A yield of the obtained product to the starting p-toluenesulfonylhydrazine was as follows.

Sources & evidence

ORD record
ord-b66895c9ca414e2e9e2c212f9b51a466
Source dataset
uspto-grants-1987_06
Patent number
US04675412

Reaction notes

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