Chloral Hydrate → HCID 57046400, compound

Participants

Reaction Steps

In 20 ml of methanol were dissolved 0.91 g (5.5 mmole) of chloral hydrate and 0.93 g (5 mmole) of p-toluenesulfonylhydrazine, and the mixture was stirred at room temperature for 60 minutes to form trichloroacetaldehyde-p-toluenesulfonylhydrazone. The reaction mixture was added to the solution of 2.35 g (16.5 mmole) of potassium disulfide dissolved in 20 ml of water for 20 minutes while maintaining the pH within 10 to 11 under room temperature, and the reaction was further continued while maintaining the pH of the reaction system within 10 to 11 by using an aqueous potassium hydroxide solution. The analysis after completion of the reaction was carried out in the same manner as in Example 1. A yield of the obtained product to the starting p-toluenesulfonylhydrazine was as follows.

Provenance & Evidence