Water → HCID 178444330, compound

HRID 653359Notes

Reaction equation

HRID 653359 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[CH2:14][CH2:13][C@H:12]([CH:15]=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:2].O>[Br-].C([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)CCC.COC(C)(C)C>[CH:15]([C@H:12]1[CH2:13][CH2:14][C@H:9]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:10][CH2:11]1)=[CH:1][CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 2

HCID 962WaterHCID 178509803HCID 178509803, compound

Product 1

HCID 178444330HCID 178444330, compoundYield 199.9%

Reagents, catalysts & solvents 2

HCID 159628Butyltriphenylphosphonium bromideCatalystHCID 15413tert-Butyl methyl etherSolvent2×

Procedure

A suspension of 3.6 g of butyltriphenylphosphonium bromide in 40 ml of t-butyl methyl ether was placed at room temperature while gassing with argon in a sulphonation flask provided with a thermometer, mechanical stirrer, dropping funnel and solid substance addition tube, treated with 1.01 g of potassium t-butylate and stirred at room temperature for a further 1 hour. The deep orange, heterogeneous mixture was subsequently cooled to -60° C. and treated within 15 minutes with a solution of 1.28 g of trans-4-(p-cyanophenyl)cyclohexanecarboxaldehyde in 10 ml of t-butyl methyl ether. The mixture was stirred for a further 60 minutes while warming slowly to -30° C., then poured into 100 ml of water and extracted three times with 50 ml of diethyl ether each time. The organic phases were washed once with 50 ml of water, dried over magnesium sulphate and concentrated. Low-pressure chromatography (0.5 bar) of the residue (3.45 g) on silica gel with ethyl acetate/petroleum ether (vol. 3:97) gave 1.52 g (99%) of p-[trans-4-(1-pentenyl)cyclohexyl]benzonitrile (trans-1-pentenyl/cis-1-pentenyl ratio about 5:95) as a colourless oil; Rf-value (ethyl acetate/petroleum ether vol. 3:97) 0.19.

Workup

  1. customwas placed at room temperature
  2. customwhile gassing with argon in a sulphonation flask
  3. customprovided with a thermometer, mechanical stirrer
  4. additionfunnel and solid substance addition tube
  5. temperatureThe deep orange, heterogeneous mixture was subsequently cooled to -60° C.
  6. stirringThe mixture was stirred for a further 60 minutes
  7. temperaturewhile warming slowly to -30° C.
  8. extractionextracted three times with 50 ml of diethyl ether each time
  9. washThe organic phases were washed once with 50 ml of water
  10. dry with materialdried over magnesium sulphate
  11. concentrationconcentrated

Sources & evidence

ORD record
ord-7327fabbeffc4d47bca90a6d36e546bf
Source dataset
uspto-grants-1987_06
Patent number
US04676604

Reaction notes

Loading…