反应详情

A solution of 2-chloro-4-phenylquinoline (4.0 g) and anhydrous piperazine (8.0 g) in toluene (4 ml) is heated under reflux for 5 hours. To the reaction mixture is added water and the resulting mixture is extracted with ethyl acetate. The extracts are dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue is chromatographed on silica gel (40 g) using chloroform as an eluent. Fractions containing the title compound are pooled and concentrated to give the title compound (4.4 g), m.p. 133°-134° C.

1. temperatureunder reflux for 5 hours
2. extractionthe resulting mixture is extracted with ethyl acetate
3. dry with materialThe extracts are dried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe residue is chromatographed on silica gel (40 g)
6. additionFractions containing the title compound
7. concentrationconcentrated