p-Anisoyl chloride → HCID 70445087, compound

HRID 653434Notes

Reaction equation

HRID 653434 reaction equation
[C:1]1([CH2:7][O:8][C:9](=[O:21])[CH2:10][C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[C:19]=2[NH:18][C:17](=[O:20])[CH2:16]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][O:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:1]1([CH2:7][O:8][C:9](=[O:21])[CH2:10][C:11]2[CH:12]=[CH:13][CH:14]=[C:15]3[C:19]=2[N:18]([C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([O:23][CH3:22])=[CH:25][CH:26]=2)[C:17](=[O:20])[CH2:16]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 8471TriethylamineHCID 53799587HCID 53799587, compound

Product 1

HCID 70445087HCID 70445087, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
70 °C

Procedure

A solution of 28.1 g (0.1 mole) 2,3-dihydro-2-oxo-1H-indole-7-acetic acid phenylmethyl ester in 400 ml of toluene is treated with 17.1 g (0.1 mole) of 4-methoxybenzoyl chloride. The mixture is heated at 70° C. with stirring and a solution of 10.2 g (0.1 mole) of triethylamine in 100 ml of toluene is added dropwise.

Sources & evidence

ORD record
ord-1ed633a05ce94bdeb32fe08393846a5b
Source dataset
uspto-grants-1987_06
Patent number
US04677112

Reaction notes

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