HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → 4-Tetrahydropyranyloxy-4,5,6,7-tetrahydrobenzo[b]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | 4-Hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophene | HCID 13911631 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Tetrahydropyranyloxy-4,5,6,7-tetrahydrobenzo[b]thiophene | HCID 13911632 | — |
Reaction Steps
A mixture of 19.0 g (0.123 mol) of product from Step A, 15.53 g (0.185 mol) of dihydropyran, 2.56 g (0.010 mol) of pyridinium-4-toluenesulfonate, and 700 ml CH2Cl2 was stirred at ambient temperature for 5 hours. The reaction mixture was washed twice with half saturated NaCl solution, dried (Na2SO4), filtered, and evaporated. The residual colorless oil was distilled (112° C., 0.05 mm Hg) yielding a quantitative amount of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04677115 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-c61e67cebbdb4b9eb5b835ece90927b8 |
| Source note | uspto-grants-1987_06 |