HRID65347

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID149026

Tetrafluoro-m-phenylenediamine dihydrochloride

C6H6Cl2F4N2

结构：CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O

HCID178455944

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O.Cl.Cl

HCID178455954

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID22242641

Methanol--water (1/1)

CH6O2

PROCEDURE

实验过程

3.14 g of the dihydrochloride of Z-Phe-His-Leu-Val-Ile-His-NH2 from Example 1 are hydrogenated for 4 hours at normal pressure in 100 ml of water/methanol (5:95) in the presence of 350 mg of palladium-on-carbon (5%). After removing the catalyst by filtration, evaporating off the solvent and drying in a high vacuum, H-Phe-His-Leu-Val-Ile-His-NH2.2HCl is obtained in the form of a colourless powder. Rf (B11)=0.26.

WORKUP

后处理

customAfter removing the catalyst
filtrationby filtration
customevaporating off the solvent
customdrying in a high vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f6560d9cb06f41d981ae71b7dadbda5e
来源数据集: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04613676
来源说明: uspto-grants-1986_09

反应 SMILES

C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:13].Cl.[NH:15](C(OCC1C=CC=CC=1)=O)[C@H:16]([C:24]([NH:26][C@H:27]([C:34]([NH:36][C@H:37]([C:42]([NH:44][C@H:45]([C:49]([NH:51][C@H:52]([C:57]([NH:59][C@H:60]([C:67]([NH2:69])=[O:68])[CH2:61][C:62]1[N:66]=[CH:65][NH:64][CH:63]=1)=[O:58])[C@H:53]([CH2:55][CH3:56])[CH3:54])=[O:50])[CH:46]([CH3:48])[CH3:47])=[O:43])[CH2:38][CH:39]([CH3:41])[CH3:40])=[O:35])[CH2:28][C:29]1[N:33]=[CH:32][NH:31][CH:30]=1)=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>O.CO.[Pd]>[NH2:15][C@H:16]([C:24]([NH:26][C@H:27]([C:34]([NH:36][C@H:37]([C:42]([NH:44][C@H:45]([C:49]([NH:51][C@H:52]([C:57]([NH:59][C@H:60]([C:67]([NH2:69])=[O:68])[CH2:61][C:62]1[N:66]=[CH:65][NH:64][CH:63]=1)=[O:58])[C@H:53]([CH2:55][CH3:56])[CH3:54])=[O:50])[CH:46]([CH3:48])[CH3:47])=[O:43])[CH2:38][CH:39]([CH3:41])[CH3:40])=[O:35])[CH2:28][C:29]1[N:33]=[CH:32][NH:31][CH:30]=1)=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[ClH:13].[ClH:13]