HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrafluoro-m-phenylenediamine dihydrochloride → H-Phe-His-Leu-Val-Ile-His-NH2.2HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | HCID 178455944 | HCID 178455944 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | H-Phe-His-Leu-Val-Ile-His-NH2.2HCl | HCID 178455954 | — |
Reaction Steps
3.14 g of the dihydrochloride of Z-Phe-His-Leu-Val-Ile-His-NH2 from Example 1 are hydrogenated for 4 hours at normal pressure in 100 ml of water/methanol (5:95) in the presence of 350 mg of palladium-on-carbon (5%). After removing the catalyst by filtration, evaporating off the solvent and drying in a high vacuum, H-Phe-His-Leu-Val-Ile-His-NH2.2HCl is obtained in the form of a colourless powder. Rf (B11)=0.26.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613676 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-f6560d9cb06f41d981ae71b7dadbda5e |
| Source note | uspto-grants-1986_09 |