Ethanol → HCID 20027830, compound

HRID 653490Notes

Reaction equation

HRID 653490 reaction equation
[CH3:1][C:2]12[CH2:8][C:6]([C:9]3[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=3)([CH2:7]1)[C:5](=[O:18])[NH:4][C:3]2=[O:19].C(O)C>COCCO.[Pd]>[NH2:15][C:12]1[CH:11]=[CH:10][C:9]([C:6]23[CH2:8][C:2]([CH3:1])([CH2:7]2)[C:3](=[O:19])[NH:4][C:5]3=[O:18])=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 702EthanolHCID 20027828HCID 20027828, compound

Product 1

HCID 20027830HCID 20027830, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 80192-MethoxyethanolSolvent

Procedure

In a manner analogous to that described in Example 12a, 3.7 g of 5-methyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione in 80 ml of 2-methoxyethanol are hydrogenated in the presence of 0.4 g of 5% palladium-on-carbon and worked up. Melting point 216° (from ethanol).

Sources & evidence

ORD record
ord-f50d021703884aa587913d6857e3085a
Source dataset
uspto-grants-1987_06
Patent number
US04677129

Reaction notes

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