HRID65351

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)O)C(C)C.C[SiH](C)OC(C(C)(C)C)C(NC(=O)CCCC[NH-])(C(O[SiH](C)C)C(C)(C)C)C(O[SiH](C)C)C(C)(C)C

HCID178445986

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)O)C(C)C.[NH-]CCCCC(=O)NC(CO)(CO)CO

HCID178445989

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21899381

Acetic acid--water (1/1)

C2H6O3

PROCEDURE

实验过程

83 mg of Z-Phe-His-Leu-Val-4-[-tris-(tert.-butyldimethylsilyloxymethyl)-methylaminocarbonyl]-butyl amide (Example 19) are stirred at room temperature for 2 hours with 6 ml of glacial acetic acid/water 2:1. After evaporating off the solvent and medium-pressure chromatography (60 g of Lichroprep® Si60, 40-60 μm, system B8), the title compound is obtained in the form of a colourless powder. Rf (methylene chloride/methanol/concentrated ammonia 70:10:1)=0.11.

WORKUP

后处理

customAfter evaporating off the solvent and medium-pressure chromatography (60 g of Lichroprep® Si60, 40-60 μm, system B8)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1787760d09d44c54a8141bf8966e1713
来源数据集: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04613676
来源说明: uspto-grants-1986_09

反应 SMILES

[NH:1]([C:38]([O:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:39])[C@H:2]([C:10]([NH:12][C@H:13]([C:20]([NH:22][C@H:23]([C:28]([NH:30][C@H:31]([C:35]([OH:37])=[O:36])[CH:32]([CH3:34])[CH3:33])=[O:29])[CH2:24][CH:25]([CH3:27])[CH3:26])=[O:21])[CH2:14][C:15]1[N:19]=[CH:18][NH:17][CH:16]=1)=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([CH:52]([C:57]([CH:75]([O:80][SiH](C)C)C(C)(C)C)([CH:66]([O:71][SiH](C)C)C(C)(C)C)[NH:58][C:59]([CH2:61][CH2:62][CH2:63][CH2:64][NH-:65])=[O:60])[O:53][SiH](C)C)(C)(C)C>C(O)(=O)C.O>[NH:1]([C:38]([O:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:39])[C@H:2]([C:10]([NH:12][C@H:13]([C:20]([NH:22][C@H:23]([C:28]([NH:30][C@H:31]([C:35]([OH:37])=[O:36])[CH:32]([CH3:34])[CH3:33])=[O:29])[CH2:24][CH:25]([CH3:27])[CH3:26])=[O:21])[CH2:14][C:15]1[N:19]=[CH:18][NH:17][CH:16]=1)=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.[OH:71][CH2:66][C:57]([CH2:52][OH:53])([CH2:75][OH:80])[NH:58][C:59]([CH2:61][CH2:62][CH2:63][CH2:64][NH-:65])=[O:60]