HCID 178445986, compound → HCID 178445989, compound

Participants

Reaction Steps

83 mg of Z-Phe-His-Leu-Val-4-[-tris-(tert.-butyldimethylsilyloxymethyl)-methylaminocarbonyl]-butyl amide (Example 19) are stirred at room temperature for 2 hours with 6 ml of glacial acetic acid/water 2:1. After evaporating off the solvent and medium-pressure chromatography (60 g of Lichroprep® Si60, 40-60 μm, system B8), the title compound is obtained in the form of a colourless powder. Rf (methylene chloride/methanol/concentrated ammonia 70:10:1)=0.11.

Provenance & Evidence