反应详情

温度

100 °C

Acetanilide (13.94 g), propionyl chloride (14.31 g) and 1,2,4-trichlorobenzene (100 ml) were warmed to 60° C. and aluminium trichloride (40.0 g) was added over 15 minutes. The mixture was heated at 100° C. for 90 minutes, cooled at 40° C. and ethanol (200 ml) was added dropwise keeping the temperature below 60° C. by means of an ice-water bath. After stirring for 30 minutes at 40° C. a homogeneous system was obtained. This was quenched with water (100 ml) at 25°-30° C. and stirred for 15 minutes. Dichloromethane (300 ml) and water (200 ml) were added and the organic layer was separated and washed with water (2×200 ml). The organic layer was evaporated to about half-volume (about 150 ml), and petroleum ether (60° C.-80° C.) (150 ml) was added at 50° C. A solid precipitated and was collected after 60 minutes of stirring to afford p-acetamidopropiophenone (15.12 g; 79%), m.p. 169°-70° C.

1. temperaturecooled at 40° C.
2. customthe temperature below 60° C.
3. customwas obtained
4. customThis was quenched with water (100 ml) at 25°-30° C.
5. stirringstirred for 15 minutes
6. additionDichloromethane (300 ml) and water (200 ml) were added
7. customthe organic layer was separated
8. washwashed with water (2×200 ml)
9. customThe organic layer was evaporated to about half-volume (about 150 ml), and petroleum ether (60° C.-80° C.) (150 ml)
10. additionwas added at 50° C
11. customA solid precipitated
12. customwas collected after 60 minutes
13. stirringof stirring