HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 178445985, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-[(Phenylmethoxy)carbonyl]-L-leucyl-L-valine | HCID 14488993 | — |
| Reactant | HCID 131714883 | HCID 131714883 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178445985 | HCID 178445985 | — |
Reaction Steps
Z-Leu-Val-methyl amide: A mixture of 100 mg of Z-Leu-Val-OH (Example 1e), 2 ml of DMF, 49 mg of HOBt and 66 mg of DCCI is left to stand at 0° for 24 hours. An excess of methylamine is added to the mixture and the whole is stirred for 2 hours at 0° and for 2 hours at room temperature. The title compound is obtained in the form of a colourless oil after flash chromatography with system N3. Rf (N7)=0.55.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613676 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-b530877672bb40398e6c59f1a43ac3a5 |
| Source note | uspto-grants-1986_09 |