HRID65357

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6329

Methylamine

CH5N

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)O)C(C)C

HCID14488993

未命名化合物

结构：CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)O)C(C)C.C[NH-]

HCID131714883

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)O)C(C)C.C[NH-]

HCID178445985

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Z-Leu-Val-methyl amide: A mixture of 100 mg of Z-Leu-Val-OH (Example 1e), 2 ml of DMF, 49 mg of HOBt and 66 mg of DCCI is left to stand at 0° for 24 hours. An excess of methylamine is added to the mixture and the whole is stirred for 2 hours at 0° and for 2 hours at room temperature. The title compound is obtained in the form of a colourless oil after flash chromatography with system N3. Rf (N7)=0.55.

WORKUP

后处理

waitis left

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b530877672bb40398e6c59f1a43ac3a5
来源数据集: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04613676
来源说明: uspto-grants-1986_09

反应 SMILES

[NH:1]([C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[C@H:2]([C:7]([NH:9][C@H:10]([C:14]([OH:16])=O)[CH:11]([CH3:13])C)=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[CH3:27][NH-:28].[NH:29](C(OCC1C=CC=CC=1)=O)[C@H:30]([C:35]([NH:37][C@H:38]([C:42]([OH:44])=[O:43])[CH:39]([CH3:41])[CH3:40])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33].C1C=[CH:57][C:58]2N(O)N=N[C:59]=2C=1.C1CC[CH:68]([N:71]=[C:72]=[N:73]C2CCCCC2)CC1.CN>CN(C=O)C>[NH:1]([C:17]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:18])[C@H:2]([C:7]([NH:9][C@H:10]([C:14]([NH:29][C@H:30]([C:35]([NH:37][C@H:38]([C:42]([OH:44])=[O:43])[CH:39]([CH3:40])[CH3:41])=[O:36])[CH2:31][CH:32]([CH3:33])[CH3:34])=[O:16])[CH2:11][C:13]1[N:73]=[CH:72][NH:71][CH:68]=1)=[O:8])[CH2:3][C:4]1[CH:5]=[CH:57][CH:58]=[CH:59][CH:6]=1.[CH3:27][NH-:28]