反应详情

The hydroxypyrimidinone of Example 60 (0.2 g, 0.61 mmol) is dissolved in 5 ml ethanol, treated with 2.5 ml 1N HCl and refluxed for 6 hours. The reaction is cooled to room temperature, quenched with water and the product extracted 3× ethyl acetate. The organics are washed, dried, filtered and concentrated in vacuo to yield a crude substance which is crystallized from ethyl acetate to give 60 mg (31.5%) of the pyrimidinone as a crystalline solid. This material is a 7:3 mixture of endo/exo bicycloalkyl isomers.

1. temperaturerefluxed for 6 hours
2. customquenched with water
3. extractionthe product extracted 3× ethyl acetate
4. washThe organics are washed
5. customdried
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customto yield a crude substance which
9. customis crystallized from ethyl acetate