反应详情

温度

80 °C

To a mixture of 2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one (J. Med. Chem. 1965, 8, 700-2) (2.43 g, 14.2 mmol) and hydroxylamine hydrochloride (2.96 g, 42.6 mmol) in EtOH (60 mL) there was added pyridine (6 mL) and the mixture was heated at 80° C. for 10 minutes. After cooling to room temperature (r.t.), the mixture was diluted with H2O (150 mL) and filtered to afford the oxime as a fluffy white solid, m.p.>220° C.

1. temperatureAfter cooling to room temperature (r.t.)
2. filtrationfiltered