HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → Z-Phe-His-Leu-Val-Ile 2-(3-indolyl)-ethyl amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 131714913 | HCID 131714913 | — |
| Reactant | Z-Phe-His-OH | HCID 178523857 | — |
| Product | Z-Phe-His-Leu-Val-Ile 2-(3-indolyl)-ethyl amide | HCID 178455951 | — |
Reaction Steps
In a manner analogous to that described in Example 1, using as starting materials 92 mg of Z-Phe-His-OH, 79 mg of H-Leu-Val-Ile-2-(3-indolyl)-ethyl amide, 32 mg of HOBt and 44 mg of DCCI, the title compound is obtained after flash chromatography (65 g of silica gel 60, 40-63 μm, eluant system B7). Rf (B7)=0.34.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613676 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-cbaca4ba7a2844679f2ae32055fe394d |
| Source note | uspto-grants-1986_09 |