反应详情

To a solution of methyl 2-amino-5-methylbenzoate (8.1 g) and triethylamine (6.0 g) in methylene chloride (50 ml) was added dropwise, while stirring under ice-cooling, valeryl chloride (6.5 g). The reaction was allowed to stir for two hours, then the reaction mixture was washed with an aqueous solution of sodium carbonate, dilute hydrochloric acid and water, followed by drying. The solvent was evaporated to dryness to give a pale brown oil (12.8 g, 99%).

1. temperaturecooling
2. stirringto stir for two hours
3. washthe reaction mixture was washed with an aqueous solution of sodium carbonate, dilute hydrochloric acid and water
4. customby drying
5. customThe solvent was evaporated to dryness