反应详情

To a solution of methyl 2-amino-5-chlorobenzoate (15 g) and triethylamine (12 ml) in methylene chloride (150 ml) was added dropwise, while stirring under ice-cooling, valeryl chloride (10 ml). The mixture was stirred at room temperature for further two hours. The reaction mixture was washed with an aqueous solution of sodium bicarbonate and water, followed by drying. The solvent was distilled off to afford a pale yellow crystals (13.4 g, 61%), m.p. 48°-49° C.

1. temperaturecooling
2. stirringThe mixture was stirred at room temperature for further two hours
3. washThe reaction mixture was washed with an aqueous solution of sodium bicarbonate and water
4. customby drying
5. distillationThe solvent was distilled off