4-(Thiophen-2-yl)pyrrolidin-2-one → 3-(Thiophen-2-yl)pyrrolidine

HRID 653753Notes

Reaction equation

HRID 653753 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:10][NH:9][C:8](=O)[CH2:7]1>C1COCC1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:7][CH2:8][NH:9][CH2:10]1

Participants

3

Reactant 1

HCID 111595394-(Thiophen-2-yl)pyrrolidin-2-one

Product 1

HCID 150299073-(Thiophen-2-yl)pyrrolidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of LiA1H4 (0.46 g) in THF (25 ml) was added the product of Example 134 (1.0 g) in THF (30 ml). After the addition was complete the reaction was heated at reflux for 4 hrs.

Workup

  1. additionAfter the addition
  2. temperaturewas heated
  3. temperatureat reflux for 4 hrs

Sources & evidence

ORD record
ord-684ebb1ddbfd480b8c7a2fd9d4e42671
Source dataset
uspto-grants-1992_07
Patent number
US05128362

Reaction notes

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