HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 178455953, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 178455956 | HCID 178455956 | — |
| Reactant | HCID 178523877 | HCID 178523877 | — |
| Solvent | Dichloromethane methanol water | HCID 21958822 | — |
| Product | HCID 178455953 | HCID 178455953 | — |
Reaction Steps
In a manner analogous to that described in Example 1, using as starting materials 23 mg of Z-His-OH, 50 mg of H-His-Leu-Val-Ile-His-NH2.2HCl, 11 mg of HOBt, 24,6 μl of ethyldiisopropylamine and 21 mg of DCCI, the title compound is obtained in the form of a grey resin after flash chromatography (32 g of silica gel 60, 40-63 μm, eluant system methylene chloride/methanol/water/glacial acetic acid 280:160:40:2). Rf (B13)=0.40.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613676 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-9c87e816bf8944c7b57e4f5a0bbea84c |
| Source note | uspto-grants-1986_09 |