HRID65376

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

HCID81531

Diisopropylethylamine

C8H19N

结构：CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O.Cl.Cl

HCID178455956

未命名化合物

结构：O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)OCc1ccccc1

HCID178523877

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)OCc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O

HCID178455953

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21958822

Dichloromethane methanol water

C2H8Cl2O2

PROCEDURE

实验过程

In a manner analogous to that described in Example 1, using as starting materials 23 mg of Z-His-OH, 50 mg of H-His-Leu-Val-Ile-His-NH2.2HCl, 11 mg of HOBt, 24,6 μl of ethyldiisopropylamine and 21 mg of DCCI, the title compound is obtained in the form of a grey resin after flash chromatography (32 g of silica gel 60, 40-63 μm, eluant system methylene chloride/methanol/water/glacial acetic acid 280:160:40:2). Rf (B13)=0.40.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9c87e816bf8944c7b57e4f5a0bbea84c
来源数据集: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04613676
来源说明: uspto-grants-1986_09

反应 SMILES

[NH:1]([C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C@H:2]([C:9]([OH:11])=O)[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1.[NH2:22][C@H:23]([C:30]([NH:32][C@H:33]([C:38]([NH:40][C@H:41]([C:45]([NH:47][C@H:48]([C:53]([NH:55][C@H:56]([C:63]([NH2:65])=[O:64])[CH2:57][C:58]1[N:62]=[CH:61][NH:60][CH:59]=1)=[O:54])[C@H:49]([CH2:51][CH3:52])[CH3:50])=[O:46])[CH:42]([CH3:44])[CH3:43])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36])=[O:31])[CH2:24][C:25]1[N:29]=[CH:28][NH:27][CH:26]=1.Cl.Cl.C1C=CC2N(O)N=NC=2C=1.C(N(C(C)C)C(C)C)C.C1CCC(N=C=NC2CCCCC2)CC1>C(Cl)Cl.CO.O>[NH:1]([C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C@H:2]([C:9]([NH:22][C@H:23]([C:30]([NH:32][C@H:33]([C:38]([NH:40][C@H:41]([C:45]([NH:47][C@H:48]([C:53]([NH:55][C@H:56]([C:63]([NH2:65])=[O:64])[CH2:57][C:58]1[N:62]=[CH:61][NH:60][CH:59]=1)=[O:54])[C@H:49]([CH2:51][CH3:52])[CH3:50])=[O:46])[CH:42]([CH3:43])[CH3:44])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36])=[O:31])[CH2:24][C:25]1[N:29]=[CH:28][NH:27][CH:26]=1)=[O:11])[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1