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HRID65377

反应详情

EQUATION

反应方程式

HRID 65377 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O
HCID178455958

未命名化合物

结构：N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)O
HCID178512880

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O
HCID178455955

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClCCl.O
溶剂HCID21958822

Dichloromethane methanol water

C2H8Cl2O2

PROCEDURE

实验过程

In a manner analogous to that described in Example 1, using as starting materials 69 mg of Z-Phe-Arg-OH, 50 mg of H-Leu-Val-Ile-His-NH2, 16 mg of HOBt and 40 mg of DCCI, the title compound is obtained in the form of a colourless powder after flash chromatography (45 g of silica gel 60, 40-63 μm, eluant system methylene chloride/methanol/water/glacial acetic acid 330:100: 19:2). Rf (S3)=0.16.