HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 178455955, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 178455958 | HCID 178455958 | — |
| Reactant | HCID 178512880 | HCID 178512880 | — |
| Solvent | Dichloromethane methanol water | HCID 21958822 | — |
| Product | HCID 178455955 | HCID 178455955 | — |
Reaction Steps
In a manner analogous to that described in Example 1, using as starting materials 69 mg of Z-Phe-Arg-OH, 50 mg of H-Leu-Val-Ile-His-NH2, 16 mg of HOBt and 40 mg of DCCI, the title compound is obtained in the form of a colourless powder after flash chromatography (45 g of silica gel 60, 40-63 μm, eluant system methylene chloride/methanol/water/glacial acetic acid 330:100: 19:2). Rf (S3)=0.16.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613676 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-03917697abbc44dd951a07c2fa6fb6e5 |
| Source note | uspto-grants-1986_09 |