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温度

0 °C

To a solution of 42.36 ml of 1 molar lithium aluminum hydride in ether is added dropwise under argon over 20 minutes a solution of ethyl 3-[[[4-(tetradecyloxy)phenyl]acetyl]amino]benzoate in 50 ml of ether and 50 ml of tetrahydrofuran. The mixture is refluxed for 3 hours, cooled to 0° C. and ethyl acetate added. Saturated sodium sulfate is added followed by ether. The mixture is filtered and the cake washed with ether. The filtrate is evaporated and the residue chromatographed on silica gel using 9:1 chloroform:ethyl acetate. The product fractions are combined and evaporated to a residue which is crystallized from hexane to give 4.5 g of the desired product as a white solid, m.p. 67°-70° C.

1. temperatureThe mixture is refluxed for 3 hours
2. filtrationThe mixture is filtered
3. washthe cake washed with ether
4. customThe filtrate is evaporated
5. customthe residue chromatographed on silica gel using 9:1 chloroform
6. customevaporated to a residue which
7. customis crystallized from hexane