反应详情

温度

0 °C

To a mixture of 9.75 g of p-aminobenzyl alcohol and 19.27 g of pyridine in 230 ml of methylene chloride cooled to 0° C. is added over 35 minutes a solution of 21.5 g of 4-tetradecyloxybenzoyl chloride in 230 ml of methylene chloride. The mixture is stirred at room temperature for 2 hours and diluted with chloroform. The mixture is heated to dissolve insolubles, washed with hot water and hot dilute hydrochloric acid then dried. The mixture is filtered hot and the solvent evaporated to a residue which is crystallized from tetrahydrofuran:hexane to give 18.1 g of the desired product as a yellow powder, m.p. 140°-145° C.

1. temperatureThe mixture is heated
2. dissolutionto dissolve insolubles
3. washwashed with hot water and hot dilute hydrochloric acid
4. customthen dried
5. filtrationThe mixture is filtered hot
6. customthe solvent evaporated to a residue which
7. customis crystallized from tetrahydrofuran