Acetonitrile → HCID 88147654, compound

HRID 653859Notes

Reaction equation

HRID 653859 reaction equation
FC(F)(F)C([O-])=O.C([NH:10][C@@H:11]1[C:32](=[O:33])[N:13]2[C:14]([C:29]([OH:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([C@@H:24]([C:26](=[O:28])[NH2:27])[CH3:25])([CH3:23])[CH3:22])[CH2:16][S:17][C@H:12]12)=O.C(#N)C.[ClH:37].CO>>[ClH:37].[NH2:10][C@@H:11]1[C:32](=[O:33])[N:13]2[C:14]([C:29]([O-:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([C@@H:24]([C:26](=[O:28])[NH2:27])[CH3:25])([CH3:23])[CH3:22])[CH2:16][S:17][C@H:12]12

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 21893726Hydrochloride methanolHCID 131717451HCID 131717451, compound

Product 1

HCID 88147654HCID 88147654, compound

Procedure

The compound (0.5 g) of Example 23 was dissolved at room temperature in a 4% (w/v) hydrochloric acid-methanol solution (5 ml), followed by stirring for 1 hour. Acetonitrile (50 ml) was added, and a precipitate thus formed was collected by filtration. The precipitate was washed with acetonitrile and acetone to obtain the target product (0.31 g). Infrared spectrum (cm-1, Nujol): 1780, 1690.

Workup

  1. customa precipitate thus formed
  2. filtrationwas collected by filtration
  3. washThe precipitate was washed with acetonitrile and acetone

Sources & evidence

ORD record
ord-4ecb812535b3482997766c6b89e2ff19
Source dataset
uspto-grants-1992_07
Patent number
US05128465

Reaction notes

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