反应详情

A mixture of (E)-3-(3-quinolinyl)-2-propenoic acid methyl ester (3.6 g, 16.9 mmol) and 5% Pd/C (0.4 g) in EtOAc (300 mL) was hydrogenated at atmospheric pressure. Upon sessation of hydrogen uptake, the catalyst was separated by filtration through a pad of Celite and the filtrate was evacuated to dryness to give the crude product (3.48 g) which was purified via flash chromatography eluting with a mixture of CH2Cl2 and ether (1:1) to give 3-quinolinepropanoic acid methyl ester (2.77 g, 12.9 mmol) in 76% yield as a glass.

1. customUpon sessation of hydrogen uptake, the catalyst was separated by filtration through a pad of Celite
2. customthe filtrate was evacuated to dryness
3. customto give the crude product (3.48 g) which
4. customwas purified via flash chromatography
5. washeluting with a mixture of CH2Cl2 and ether (1:1)