Water → HCID 15057619, compound

HRID 654020Notes

Reaction equation

HRID 654020 reaction equation
[OH:1][CH:2]([CH:29]1[CH2:33][O:32]C(C)(C)[O:30]1)[CH2:3][NH:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14](=[O:28])(=[O:27])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=2[C:23]([F:26])([F:25])[F:24])[CH:9]=1)(=[O:7])=[O:6].O>CO>[OH:1][CH:2]([CH:29]([OH:30])[CH2:33][OH:32])[CH2:3][NH:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14](=[O:28])(=[O:27])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=2[C:23]([F:25])([F:26])[F:24])[CH:9]=1)(=[O:6])=[O:7]

Participants

4

Reactant 2

HCID 962WaterHCID 15057618HCID 15057618, compound

Product 1

HCID 15057619HCID 15057619, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.78 g (5 mmol) of 3-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]-benzenesulfonic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide] is dissolved in 10 ml of methanol, 10 ml of water and a catalytic amount of cation exchanger Amberlyst 15 are added and boiled for 1 hour. The ion exchanger is filtered off and the filtrate is evaporated to dryness. 2.12 g (4.12 mmol)=82.3% of the theoretical yield of the product is obtained as an amorphous solid.

Workup

  1. filtrationThe ion exchanger is filtered off
  2. customthe filtrate is evaporated to dryness
  3. custom2.12 g (4.12 mmol)=82.3% of the theoretical yield of the product is obtained as an amorphous solid

Sources & evidence

ORD record
ord-f5cb8fec90d246be9f7626ada8f95f59
Source dataset
uspto-grants-1992_07
Patent number
US05130119

Reaction notes

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