Water → HCID 15057619, compound

Participants

Reaction Steps

2.78 g (5 mmol) of 3-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]-benzenesulfonic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide] is dissolved in 10 ml of methanol, 10 ml of water and a catalytic amount of cation exchanger Amberlyst 15 are added and boiled for 1 hour. The ion exchanger is filtered off and the filtrate is evaporated to dryness. 2.12 g (4.12 mmol)=82.3% of the theoretical yield of the product is obtained as an amorphous solid.

Provenance & Evidence