反应详情

温度

60 °C

4.74 g (10 mmol) of 3-[N-(2,4,6-trifluorophenyl)sulfamoyl]-benzoic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethylamide] is dissolved in a mixture of 50 ml of ethanol and 20 ml of water and the solution is acidified to pH 1 with dilute hydrochloric acid. At this pH, it is stirred for 4 hours at 60° C. The solution is then adjusted to pH 6.6 with anion exchanger Amberlite IRA 67, filtered and evaporated to dryness in a vacuum. The solid amorphous residue is dried in a vacuum at 50° C. 3.61 g (8.32 mmol)=83.2% of the theoretical yield is obtained as an amorphous solid.

1. filtrationfiltered
2. customevaporated to dryness in a vacuum
3. customThe solid amorphous residue is dried in a vacuum at 50° C
4. custom3.61 g (8.32 mmol)=83.2% of the theoretical yield
5. customis obtained as an amorphous solid