5-Fluoro-2-hydroxy-3-nitro-N-(2,2,2-trifluoroethyl)benzamide → HCID 19888152, compound
Reaction equation
[F:1][C:2]([F:19])([F:18])[CH2:3][NH:4][C:5](=[O:17])[C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]([N+:13]([O-])=O)[C:7]=1[OH:16]>C(O)C>[F:19][C:2]([F:1])([F:18])[CH2:3][NH:4][C:5](=[O:17])[C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]([NH2:13])[C:7]=1[OH:16]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
7.05 g (25 mmol) of 5-fluoro-2-hydroxy-3-nitrobenzoic acid-(2,2,2,-trifluoro-ethyl)amide is dissolved in 70 ml of ethanol, 5.65 (25 mmol) of SnCl2 ·H2O is added and the suspension is stirred for 2 hours at 70° C. The reaction mixture is then concentrated by evaporation to oil and used in the next reaction without purification.
Workup
- concentrationThe reaction mixture is then concentrated by evaporation to oil
- customused in the next reaction without purification
Sources & evidence
- ORD record
- ord-8f8298e232624bc189a11e60237550bf
- Source dataset
- uspto-grants-1992_07
- Patent number
- US05130119
Reaction notes
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