反应详情

Analogously to the instructions for Example 8, 2.2 g (6.98 mmol) of 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]-acetic acid methyl ester in dioxane is saponified with aqueous NaOH. After acidification, extraction and crystallization from ethyl acetate/hexane, 1.96 g=93.2% of the theoretical yield of crystals is obtained. Melting point 138°-140° C.

1. extractionAfter acidification, extraction and crystallization from ethyl acetate/hexane, 1.96 g=93.2% of the theoretical yield of crystals
2. customis obtained