HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic Acid Methyl Ester | HCID 54294492 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]acetic acid | HCID 19764008 | — |
Reaction Steps
Analogously to the instructions for Example 8, 2.2 g (6.98 mmol) of 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]-acetic acid methyl ester in dioxane is saponified with aqueous NaOH. After acidification, extraction and crystallization from ethyl acetate/hexane, 1.96 g=93.2% of the theoretical yield of crystals is obtained. Melting point 138°-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05130119 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-7a1dc14c2a5d4a06ba965a6c59ced284 |
| Source note | uspto-grants-1992_07 |