Sodium Hydroxide → 3-Fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid

HRID 654053Notes

Reaction equation

HRID 654053 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[C:9]([S:10](=[O:17])(=[O:16])[NH:11][C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=[C:6]([F:18])[CH:5]=1.[OH-].[Na+]>O1CCOCC1>[F:18][C:6]1[CH:5]=[C:4]([C:9]([S:10](=[O:16])(=[O:17])[NH:11][C:12]([F:14])([F:15])[F:13])=[CH:8][CH:7]=1)[C:3]([OH:19])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 538358983-Fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid methyl ester

Product 1

HCID 198881613-Fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Analogously to Example 21(b), 2.41 g (8 mmol) of 3-fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid methyl ester in aqueous dioxane is saponified with NaOH and isolated. 1.55 g=67.3% of the theoretical yield is obtained as a partially crystalline product.

Workup

  1. customisolated
  2. custom1.55 g=67.3% of the theoretical yield
  3. customis obtained as a partially crystalline product

Sources & evidence

ORD record
ord-c1e3d1a889934aac9ddb837c969f0953
Source dataset
uspto-grants-1992_07
Patent number
US05130119

Reaction notes

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