HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-Fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid methyl ester | HCID 53835898 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid | HCID 19888161 | — |
Reaction Steps
Analogously to Example 21(b), 2.41 g (8 mmol) of 3-fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid methyl ester in aqueous dioxane is saponified with NaOH and isolated. 1.55 g=67.3% of the theoretical yield is obtained as a partially crystalline product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05130119 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-c1e3d1a889934aac9ddb837c969f0953 |
| Source note | uspto-grants-1992_07 |