Ethanol → HCID 19888170, compound

HRID 654056Notes

Reaction equation

HRID 654056 reaction equation
[OH:1][CH:2]1[CH2:8][O:7]C(C)(C)[O:5][CH2:4][CH:3]1[NH:11][C:12](=[O:34])[C:13]1[CH:18]=[CH:17][C:16]([S:19](=[O:33])(=[O:32])[NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[C:23]([C:28]([F:31])([F:30])[F:29])[CH:22]=2)=[CH:15][CH:14]=1.C(O)C>O>[OH:1][CH:2]([CH2:8][OH:7])[CH:3]([NH:11][C:12](=[O:34])[C:13]1[CH:18]=[CH:17][C:16]([S:19](=[O:32])(=[O:33])[NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[C:23]([C:28]([F:30])([F:31])[F:29])[CH:22]=2)=[CH:15][CH:14]=1)[CH2:4][OH:5]

Participants

4

Reactant 2

HCID 702EthanolHCID 19888146HCID 19888146, compound

Product 1

HCID 19888170HCID 19888170, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

2 g (3.95 mmol) of 4-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]-benzoic acid-(6-hydroxy-2,2-dimethyl-1,3-dioxepan-5-yl)-amide as well as 2 ml of cation exchanger in H. form are added to a solution of 10 ml of ethanol and 5 ml of distilled water and warmed for 90 minutes on the water bath. It is filtered from the exchanger, rewashed with distilled water, evaporated to dryness in a vacuum, and again taken up in water and by freeze-drying of this solution, 1.55 g=84.2% of the theoretical yield is obtained as an amorphous solid.

Workup

  1. filtrationIt is filtered from the exchanger
  2. customevaporated to dryness in a vacuum
  3. customby freeze-drying of this solution, 1.55 g=84.2% of the
  4. customtheoretical yield
  5. customis obtained as an amorphous solid

Sources & evidence

ORD record
ord-42bc03449e714f48adcae1a271601baf
Source dataset
uspto-grants-1992_07
Patent number
US05130119

Reaction notes

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